Therapeutic monitoring of plasma level of drug is done when using all of the following drugs except:
## Core Concept
Therapeutic drug monitoring (TDM) involves measuring the plasma concentration of drugs to optimize their efficacy and minimize toxicity. This practice is particularly important for drugs with a narrow therapeutic index, where the difference between an effective dose and a toxic dose is small.
## Why the Correct Answer is Right
The correct answer, , is associated with a drug for which therapeutic monitoring of plasma levels is not typically required. This could be due to a variety of factors, including a wide therapeutic index, a predictable pharmacokinetic profile, or the availability of reliable clinical markers for efficacy and toxicity.
## Why Each Wrong Option is Incorrect
* **Option A:** - Drugs like have a narrow therapeutic index, making TDM crucial to avoid toxicity while ensuring efficacy.
* **Option B:** - For drugs like , monitoring plasma levels helps in adjusting doses to achieve therapeutic effects while minimizing adverse effects.
* **Option D:** - requires TDM due to its narrow therapeutic index and variability in pharmacokinetics among patients.
## Clinical Pearl / High-Yield Fact
A key concept in pharmacology is that drugs with a narrow therapeutic index require careful monitoring to prevent toxicity. Examples include digoxin, lithium, and certain anticonvulsants.
## Correct Answer: .