The vitamin K dependent protein C and S are characterised by their ability to inactivate factor:
Correct Answer: 8a and 5a
Description: Sequence of Events Involved in the Activation of Plasminogen
During intravascular clotting, the endothelium of the blood vessel secretes a thrombin-binding protein, the thrombomodulin. It is secreted by the endothelium of all the blood vessels, except the minute vessels of brain.
Thrombomodulin combines with thrombin and forms a thrombomodulin-thrombin complex.
Thrombomodulin-thrombin complex activates protein C.
Activated protein C inactivates factor V and VIII in the presence of a cofactor called protein S.
Protein C also inactivates the t-PA inhibitor.
Now, the t-PA becomes active.
Activated t-PA and lysosomal enzymes activate plasminogen to form plasmin. Plasminogen is also activated by thrombin and u-PA.
Category:
Physiology
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