The typical ‘Orphan-Annie eye’ nucleus is described in –
Correct Answer: Papillary carcinoma of thyroid
Description: Papillary carcinoma: Accounts for 85% of thyroid malignancy in iodine-deficient areas Most common thyroid cancer in children and in persons exposed to external radiation Most often in women between 30-40 years Excellent prognosis Characteristic nuclear features: Ground glass (Orphan Annie) nuclei pseudoinclusions Nuclear grooves. Nuclear features are used as diagnostic criteria even in the absence of papillae. Papillary carcinoma: Most commonly spreads through lymphatics. Papillary carcinoma: Metastasize through lymphatics and have an excellent prognosis.
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