Physiology The type of hemoglobin that has least affinity for 2,3-Diphosphoglycerate (2,3-DPG) or (2,3-BPG) is: A HbA B HbF C HB D HgA2 💡 Explanation The type of hemoglobin that has least affinity for 2,3-Diphosphoglycerate (2,3-DPG) or (2,3-BPG) is: ✓ Correct Answer: B. HbF