Physiology The tubuloglomerular feedback is mediated by: A Sensing of Na+ concentration in the macula densa B Sensing of Cl+ concentration in macula densa C Sensing NaCl concentration in the macula densa D Opening up of voltage gated Na+ channels in afferent aeriole 💡 Explanation The tubuloglomerular feedback is mediated by: ✓ Correct Answer: C. Sensing NaCl concentration in the macula densa