**Core Concept**
Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare skin condition characterized by sudden onset of fever, leukocytosis, and tender, erythematous skin lesions. It is often associated with an underlying systemic condition, such as infection or autoimmune disease.

**Why the Correct Answer is Right**
The treatment of Sweet syndrome involves addressing the underlying cause, as well as managing the skin manifestations. **Corticosteroids**, particularly prednisone, are the mainstay of treatment for Sweet syndrome. They help reduce inflammation, decrease the severity of skin lesions, and alleviate systemic symptoms. The mechanism of action involves the suppression of inflammatory cytokines and reduction of neutrophil infiltration into the skin.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because antibiotics are not the primary treatment for Sweet syndrome, unless the underlying cause is a bacterial infection.
**Option B:** This option is incorrect because biologics, such as TNF-alpha inhibitors, may be used in certain cases of Sweet syndrome, but they are not the first-line treatment.
**Option C:** This option is incorrect because antihistamines may be used to manage pruritus and skin symptoms, but they do not address the underlying inflammatory process.

**Clinical Pearl / High-Yield Fact**
The characteristic skin lesions of Sweet syndrome are often described as "papules, plaques, or nodules" that are tender to the touch, and may be accompanied by fever, leukocytosis, and systemic symptoms.

**Correct Answer: C. Corticosteroids, particularly prednisone.**