Pharmacology The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they : A Cause sodium excretion B Increase the clearance of antihypertensive drugs C Decrease the absorption of antihypertensive drugs D Decrease the synthesis of vascular prostacyclin 💡 Explanation The therapeutic efficacy of antihypertensive drugs is blunted by NSAIDs because they : ✓ Correct Answer: D. Decrease the synthesis of vascular prostacyclin