Pharmacology The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they: A Cause sodium excretion B Increase the clearance of antihypeensive drugs C Decrease the absorption of antihypeensive drugs D Decrease the synthesis of vascular prostacyclin 💡 Explanation The therapeutic efficacy of antihypeensive drug is blunted by NSAIDs because they: ✓ Correct Answer: D. Decrease the synthesis of vascular prostacyclin