Surgery The tendency of colonic carcinoma to metastasize is best assessed by: A Size of tumor B Carcinoembryonic antigen (CEA) levels C Depth of penetration of bowel wall D Proportion of bowel circumference involved. 💡 Explanation The tendency of colonic carcinoma to metastasize is best assessed by: ✓ Correct Answer: C. Depth of penetration of bowel wall