The synthesis of 1 peptide bond involves hydrolysis of
**Core Concept**
The synthesis of a peptide bond is a crucial step in protein biosynthesis, where two amino acids are joined together by a peptide linkage. This process is facilitated by the enzyme peptidyl transferase, which catalyzes the formation of a peptide bond between the carboxyl group of one amino acid and the amino group of another.
**Why the Correct Answer is Right**
During peptide bond synthesis, the energy from the hydrolysis of GTP (guanosine triphosphate) is used to drive the formation of a peptide bond. This energy is transferred to the peptide bond through the action of the enzyme peptidyl transferase, which catalyzes the condensation reaction between the amino and carboxyl groups of the two amino acids. The hydrolysis of GTP is essential for the initiation and elongation of protein synthesis.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because the synthesis of a peptide bond does not involve the hydrolysis of ATP (adenosine triphosphate), although ATP is involved in other steps of protein synthesis, such as the initiation and elongation phases.
* **Option B:** This option is incorrect because the synthesis of a peptide bond does not involve the hydrolysis of NADH (nicotinamide adenine dinucleotide + hydrogen), which is a coenzyme involved in redox reactions and energy metabolism.
* **Option C:** This option is incorrect because the synthesis of a peptide bond does not involve the hydrolysis of CoA (coenzyme A), which is a coenzyme involved in fatty acid metabolism and the synthesis of acetyl-CoA.
**Clinical Pearl / High-Yield Fact**
The peptidyl transferase center is a unique region of the ribosome where peptide bond synthesis occurs. This region is responsible for catalyzing the condensation reaction between the amino and carboxyl groups of the two amino acids, and is essential for the synthesis of all proteins.
**Correct Answer:** GTP. The synthesis of 1 peptide bond involves hydrolysis of GTP.