Biochemistry The rate-limiting step in the synthesis of bile acids is catalyzed by: A 12a-Hydroxylase B 7a-Hydroxylase C HMG coA reductase inhibitors and bile acid sequestrant D 25-hydroxycholecalciferol 1-hydroxylase 💡 Explanation The rate-limiting step in the synthesis of bile acids is catalyzed by: ✓ Correct Answer: B. 7a-Hydroxylase