**Core Concept**
Pancreatic pseudocysts are complications of pancreatitis, characterized by a collection of fluid surrounded by a wall of granulation tissue, but without an epithelial lining. The prime cause of death from pancreatic pseudocysts is related to the risk of rupture and subsequent complications.

**Why the Correct Answer is Right**
The correct answer is related to the risk of rupture of the pseudocyst, which can lead to severe bleeding, peritonitis, or even death. This is due to the erosion of the pseudocyst into nearby major blood vessels or the peritoneal cavity. The most common cause of death from pancreatic pseudocysts is hemorrhage due to erosion into the splenic artery or other major vessels. The risk of rupture is higher in patients with a large pseudocyst, those with a history of recurrent pancreatitis, and those with a high output of pancreatic secretions.

**Why Each Wrong Option is Incorrect**
* **Option B:** While infection of the pseudocyst (pyogenic abscess) is a serious complication, it is not the prime cause of death. Infection can lead to sepsis, but this is a secondary complication.
* **Option C:** Malignancy within the pseudocyst is rare and not the primary cause of death. While it is a serious complication, it is not as common as rupture and hemorrhage.
* **Option D:** Obstruction of the common bile duct or pancreatic duct by the pseudocyst can cause jaundice or pancreatitis, but is not the prime cause of death.

**Clinical Pearl / High-Yield Fact**
To remember the prime cause of death from pancreatic pseudocysts, recall the acronym "RIP": Rupture, Infection, and Perforation are all serious complications, but rupture is the most common cause of death.

**Correct Answer: C. Hemorrhage.**