Pharmacology The primary mechanism of action of local anesthetics is A Blockade of voltage-gated sodium channels B Stimulation of voltage-gated N-type calcium channels C Activation of ligand-gated potassium channels D Blockade the GABA-gated chloride channels 💡 Explanation The primary mechanism of action of local anesthetics is ✓ Correct Answer: A. Blockade of voltage-gated sodium channels