Pharmacology The primary mechanism of action of fluoride on topical application is – A Conversion of hydroxyapatite to fluoroapatite by replacing the OH- ions B Inhibition of plaque bacteria C Form a reservoir in saliva D Improvement in tooth morphology 💡 Explanation The primary mechanism of action of fluoride on topical application is - ✓ Correct Answer: A. Conversion of hydroxyapatite to fluoroapatite by replacing the OH- ions