Physiology The presence of large quantities of unabsorbed solutes in the renal tubule causes an increase in urine volume this is called A Osmotic diuresis B Osmotic natriuresis C Water intoxication D Water diuresis 💡 Explanation The presence of large quantities of unabsorbed solutes in the renal tubule causes an increase in urine volume this is called ✓ Correct Answer: A. Osmotic diuresis