Physiology The presence of large quantities of un-reabsorbed solutes in the renal tubule causes an increase in urine volume is called: A Osmotic diuresis B Osmotic natriuresis C Water intoxication D Water dieresis 💡 Explanation The presence of large quantities of un-reabsorbed solutes in the renal tubule causes an increase in urine volume is called: ✓ Correct Answer: A. Osmotic diuresis