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The positive inotropic effect of digitalyzers is due to invitation of Na+/K+ ATPase pump in cardiac muscle cell membrane leading to

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Decrease the activity of Na+/Ca+ exchanger causing decrease the influx of sodium and decreased efflux of Ca++ in the sarcolemma
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Ref-Goodman and Gillman 12/e p802,803 The positive inotropic effect of digitalis is due to inhibition of Na+/K+ ATPase pump in cardiac muscle cell membrane leading to decreased activity of Na+/Ca++ exchanger causing decrease the influx of sodium and decreased efflux of CA++ in the sarcolemma
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