TRH stimulates the secretion of prolactin as well as TSH, Normally it does not affect growth hormone secretion but in acromegaly TRH induced growth hormonal stimulation Occurs.Note: "In prolactinomas paradoxical response of TRH to prolactin occurs". In normal individuals, TRH stimulates prolactin release Where as in prolactinomas There is little or no rise in prolactin in response to TRH.