Physiology The nerve impulse which leads to initiation of muscle contraction ? A Causes opening of the calcium channels which leads to increase in calcium ion concentration with use of sarcomere B Causes both the plasma membrane and the T tubules to undergo hyperpolarization C Inhibits Sodium entry in sarcomere D Is inhibited by binding of acetylcholine to receptors in the sarcoplasmic reticulum 💡 Explanation The nerve impulse which leads to initiation of muscle contraction ? ✓ Correct Answer: A. Causes opening of the calcium channels which leads to increase in calcium ion concentration with use of sarcomere