Pharmacology The most impoant mechanism by which gram negative bacilli acquire chloramphenicol resistance is: A Decreased permeability into the bacterial cell B Acquisition of a plasmid encoded for chloramphenicol acetyl transferase C Lowered affinity of the bacterial ribosome for chloramphenicol D Switching over from ribosomal to mitochondrial protein synthesis 💡 Explanation The most impoant mechanism by which gram negative bacilli acquire chloramphenicol resistance is: ✓ Correct Answer: B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferase