The MOST frequent genetic aberration associated with pancreatic malignancy is:
Correct Answer: KRAS mutation
Description: The most frequent genetic aberrations in pancreatic cancer is KRAS mutations seen in 60-75% of pancreatic cancers. The tumor-suppressor genes p16, p53, and SMAD4 are inactivated. SMAD4 gene is deleted in 55% of pancreatic tumors. SMAD4 gene inactivation is associated with poorer survival. Overexpression and/or aberrant activation of c-Src is also observed. Ref: Harrison, Edition -18, Page-787.
Category:
Pathology
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