**Core Concept**
Aplastic anemia is a rare, potentially life-threatening failure of the bone marrow to produce blood cells. Inherited forms of aplastic anemia are typically caused by mutations in genes involved in the regulation of hematopoiesis.
**Why the Correct Answer is Right**
The most common inherited form of aplastic anemia is Fanconi anemia, a rare genetic disorder characterized by congenital anomalies, bone marrow failure, and increased risk of cancer. Fanconi anemia is caused by mutations in the FANCA, FANCC, FANCD1 (BRCA2), FANCD2, FANCE, FANCI, FANCL, FANCM, FANCN (PALB2), FANCO (RAD51C), or FANCJ (BRIP1) genes, which are involved in the repair of interstrand DNA crosslinks. The defective DNA repair mechanism leads to genetic instability, bone marrow failure, and increased risk of malignancies.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not specified. Please verify the question for accurate options.
* **Option B:** This option is not specified. Please verify the question for accurate options.
* **Option C:** This option is not specified. Please verify the question for accurate options.
* **Option D:** This option is not specified. Please verify the question for accurate options.
**Clinical Pearl / High-Yield Fact**
Fanconi anemia is an autosomal recessive disorder, meaning that affected individuals are homozygous for a mutated gene. The diagnosis of Fanconi anemia is often suspected based on clinical features, such as congenital anomalies, bone marrow failure, and increased risk of cancer, and confirmed by genetic testing.
**Correct Answer: A. Fanconi anemia.**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.