Typical B cell CLL/small lymphocytic lymphoma treatment: The most common treatments for patients with typical B cell CLL/small lymphocytic lymphoma have been chlorambucil or fludarabine. Chlorambucil can be administered orally while fludarabine is administered IV Fludarabine is the more active agent and is the only drug associated with a significant incidence of complete remission. For young patients regimens containing fludarabine are the treatment of choice. Bendamustine also used as the primary agent in treatment. Ref: Harrison, E-18,P-926