The most appropriate drug used for chelation therapy in beta thalassemia major is –
Correct Answer: Oral deferiprone
Description: Ans. is 'b' i.e., Oral deferiprone Desferrioxamine is poorly absorbed from GIT and hence not recommended for oral administration, although it continues to be the chelating agent of choice for parentral administration. o Deferiprone is a recently introduced orally active iron chelating agent meant to be used as an alternative to injected desferrioxamine. o Oral Deferiprone is prefered over oral desferrioxamine. Remember o For acute iron poisoning desferioxamine is the DOC. o For chronic iron overload, e.g. thalassemia, oral deferipone is the DOC.
Category:
Pharmacology
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