Pharmacology The mechanism of anticancer action of fluorouracil is: A Cross linking of double stranded DNA and the resulting inhibition of DNA replication and transcription B Cytotoxicity resulting from a metabolite that interferes with the production of dTMP C Irreversible inhibition of dihydrofolic acid reductase D Inhibiting the formation of mitotic spindle 💡 Explanation The mechanism of anticancer action of fluorouracil is: ✓ Correct Answer: B. Cytotoxicity resulting from a metabolite that interferes with the production of dTMP