Pharmacology The major limitation in the use of clozapine for treatment of schizophrenia is A Its potential to cause agranulocytosis B High incidence of extrapyramidal side effects C Production of hyperprolactinemia D Its inability to benefit negative symptoms of schizophrenia 💡 Explanation The major limitation in the use of clozapine for treatment of schizophrenia is ✓ Correct Answer: A. Its potential to cause agranulocytosis