Skin The main cytokine, involved in erythema nodusum leprosum (ENL) reaction is: A Interleukin-2 B Interferon-gamma C Tumor necrosis factor-alpha D Macrophage colony stimulating factor 💡 Explanation The main cytokine, involved in erythema nodusum leprosum (ENL) reaction is: ✓ Correct Answer: C. Tumor necrosis factor-alpha