• Squamous cell carcinoma of scrotumQ, most commonly resulted from exposure to environmental carcinogens including chimney soot, tars, paraffin and petroleum products. • Superficial inguinal lymph nodes are the first lymph nodes involved.  Risk Factors • Most cases results from poor hygiene and chronic inflammation. Diagnosis • Diagnosis is established by biopsy of scrotal skin. Treatment • Wide excision with 2 cm margins should be performed for malignant tumors. • Prognosis correlates with presence or absence of nodal involvement.