Biochemistry The immediate precursor in the formation of acetoacetate from acetyl-CoA in the liver is: A Mevalonate B HMG-CoA C Acetoacetyl-CoA D 3-hydroxyl-butyryl-CoA 💡 Explanation The immediate precursor in the formation of acetoacetate from acetyl-CoA in the liver is: ✓ Correct Answer: B. HMG-CoA