The ideal chelating agent in case of G6PD deficiency is
**Core Concept**
The ideal chelating agent in the context of G6PD deficiency refers to the preferred treatment for lead poisoning in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. This concept is based on the understanding of the enzyme's role in protecting red blood cells from oxidative stress and the mechanism of lead poisoning.
**Why the Correct Answer is Right**
In G6PD deficiency, red blood cells are more susceptible to oxidative damage, which can be exacerbated by lead poisoning. The correct chelating agent should be able to effectively remove lead from the body while minimizing oxidative stress on red blood cells. Succimer (DMSA) is a safe and effective chelating agent for lead poisoning, especially in children, and is not significantly oxidizing, making it a suitable choice for patients with G6PD deficiency.
**Why Each Wrong Option is Incorrect**
**Option A:** Penicillamine is a chelating agent used for heavy metal poisoning, but it can cause hemolysis in G6PD deficient patients due to its oxidizing properties.
**Option B:** Dimercaprol is another chelating agent used for heavy metal poisoning, but it can also cause hemolysis in G6PD deficient patients due to its oxidizing properties.
**Option C:** Deferoxamine is a chelating agent used for iron poisoning, not lead poisoning, and is not suitable for patients with G6PD deficiency.
**Clinical Pearl / High-Yield Fact**
In patients with G6PD deficiency, it's essential to use chelating agents that are not oxidizing to minimize the risk of hemolysis. Succimer (DMSA) is a safer alternative to other chelating agents in this population.
**Correct Answer: D. Succimer**