Pathology The highest life time risk of pancreatic malignancy is seen with: A Peutz-Jeghers syndrome B Hereditary nonpolyposis colorectal cancer C Li-Fraumeni syndrome D Familial adenomatous polyposis 💡 Explanation The highest life time risk of pancreatic malignancy is seen with: ✓ Correct Answer: A. Peutz-Jeghers syndrome