The function of vitamin K largely depends on which mineral –
Correct Answer: Calcium
Description: Ans. is 'b' i.e.. Calcium o Vitamin K plays an important role in blood coagulation for it is required for the post-translational processing of several clotting factors (factor II, VII, IX and X).o Mcturation of these clotting factors requires the conversion of glutamyl residues of precursor proteins into g- ca rbox vgluta mate (Gla) residues by addition of carboxylate group. This carboxylation of glutamyl resdiue is vitaminK dependent.o The g-carboxyglutamate (Gla) residues so formed serve as binding site for calcium ions. Each Gla contains two negative charges which chelate the positive calcium ion.o After binding to Gla residue on activated clotting factor, calcium binds with negatively charged phospholipids present on the platelet cell membrane.o In this way, bridging of the phospholipids the Gla residue ofprothromin occurs via calcium ion.
Category:
Biochemistry
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