The following statements regarding streptokinase are true, except:
**Core Concept**
Streptokinase is a thrombolytic agent derived from Streptococcus equisimilis, used to dissolve intravascular thrombi in acute ischemic strokes, myocardial infarctions, and pulmonary embolisms. It acts by activating the fibrinolytic system, which degrades fibrin clots.
**Why the Correct Answer is Right**
Streptokinase works by binding to the plasminogen molecule, converting it into its active form, plasmin. Plasmin then degrades fibrin clots by cleaving the fibrinopeptides from fibrin. This process results in the dissolution of the thrombus, restoring blood flow to the affected area. However, streptokinase also has a systemic effect, activating plasminogen in the bloodstream, which can lead to bleeding complications.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because streptokinase is indeed used to treat acute ischemic strokes, making it a true statement.
**Option B:** This option is incorrect because streptokinase is indeed derived from Streptococcus equisimilis, not Streptococcus pyogenes, making it a true statement.
**Option C:** This option is incorrect because streptokinase is indeed used to dissolve intravascular thrombi, making it a true statement.
**Clinical Pearl / High-Yield Fact**
It's essential to weigh the risks and benefits of thrombolytic therapy with streptokinase, as it can lead to significant bleeding complications, including intracranial hemorrhage.
**Correct Answer: C.**