**Core Concept**
The management of asthma involves avoiding triggers and medications that can exacerbate the condition. In this context, the question is likely referring to medications or substances that can worsen asthma symptoms or interact with asthma medications.

**Why the Correct Answer is Right**
Beta-2 agonists, such as salbutamol, are commonly used as rescue medications in asthma. However, other beta-agonists like **β-2 antagonists (e.g., propranolol)** can block the effects of beta-2 agonists and worsen asthma symptoms. This is because beta-2 antagonists can compete with beta-2 agonists for receptor binding, leading to a decrease in bronchodilation and an increase in bronchoconstriction.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is not provided.
**Option B:** This option is not provided.
**Option C:** This option is not provided.

**Clinical Pearl / High-Yield Fact**
When managing asthma patients, it's essential to be aware of medications that can interact with asthma medications or worsen symptoms. Beta-2 antagonists, like propranolol, should be avoided in patients with asthma, and alternative medications should be chosen when necessary.

**Correct Answer:** A. Beta-2 antagonists (e.g., propranolol)