The following drugs can cause eosinophilic pneumonia except –
**Question:** The following drugs can cause eosinophilic pneumonia except -
A. Prednisolone
B. Azithromycin
C. Methotrexate
D. Ibuprofen
**Correct Answer:** D. Ibuprofen
**Core Concept:**
Eosinophilic pneumonia is a type of interstitial lung disease characterized by the accumulation of eosinophils in the lung parenchyma. This condition can be caused by various factors, including infections, drugs, and autoimmune disorders. Understanding the medications associated with eosinophilic pneumonia helps in identifying and avoiding such complications.
**Why the Correct Answer is Right:**
Ibuprofen (Option D) is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, inflammation, and fever reduction. While NSAIDs can cause interstitial lung disease, it is rare for them to directly cause eosinophilic pneumonia. In contrast, other drugs listed can directly or indirectly lead to eosinophilic pneumonia.
**Why Each Wrong Option is Incorrect:**
A. Prednisolone (Option A) is a corticosteroid used to suppress the immune system and reduce inflammation. It is associated with eosinophilic pneumonia as a potential side effect due to its immunosuppressive effects.
B. Azithromycin (Option B) is a macrolide antibiotic that can cause eosinophilic pneumonia due to its immunosuppressive properties, which can lead to an increased risk of infections and subsequent eosinophilic pneumonia.
C. Methotrexate (Option C) is an immunosuppressive drug used in the treatment of autoimmune diseases. It is known to cause eosinophilic pneumonia due to its immunosuppressive effects and interference with the clearance of parasitic infections.
**Clinical Pearl:**
Eosinophilic pneumonia can be triggered by various factors, including infections, medications, and autoimmune disorders. When evaluating patients with lung symptoms, it is essential to consider the potential etiologies and their associated medications or conditions. This helps in promptly diagnosing and treating the underlying cause, preventing further lung damage and improving patient outcomes.