**Core Concept**
The question is about **beta-thalassemia major**, a severe form of thalassemia characterized by reduced or absent production of the beta-globin chains of hemoglobin. This condition leads to severe anemia, requiring regular blood transfusions.

**Why the Correct Answer is Right**
Since the correct answer is not provided, let's discuss the general features of beta-thalassemia major, which include severe anemia, growth retardation, and expansion of bone marrow spaces, leading to skeletal deformities. Patients often require frequent blood transfusions, which can lead to iron overload.

**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific details of option A, we cannot determine why it is incorrect.
**Option B:** Similarly, without the details of option B, its incorrectness cannot be explained.
**Option C:** And option C's incorrectness also cannot be discussed without its specifics.
**Option D:** The same applies to option D.

**Clinical Pearl / High-Yield Fact**
A key point to remember about beta-thalassemia major is that it requires lifelong management, including regular transfusions and iron chelation therapy to prevent complications from iron overload.

**Correct Answer:** Correct Answer: D.