The following are selective beta blockers except
**Core Concept**
Selective beta blockers are a class of medications that specifically target beta-adrenergic receptors, either beta-1 (β1) or beta-2 (β2), to produce a more targeted therapeutic effect. This is in contrast to non-selective beta blockers that inhibit both β1 and β2 receptors. The selective action on β1 receptors is particularly useful in managing conditions such as hypertension, angina, and arrhythmias.
**Why the Correct Answer is Right**
The correct answer is a selective beta blocker that specifically targets β1 receptors, thereby reducing heart rate, contractility, and cardiac output without affecting airway resistance or peripheral vasculature. This is achieved through the inhibition of the β1-adrenergic receptor, which is primarily located in the heart. The β1 receptor is coupled to Gs-protein, leading to an increase in intracellular cAMP, which ultimately stimulates the heart muscle to contract.
**Why Each Wrong Option is Incorrect**
**Option A:** This is a non-selective beta blocker that inhibits both β1 and β2 receptors, leading to a decrease in heart rate, contractility, and cardiac output, as well as a decrease in airway resistance and peripheral vasculature.
**Option B:** This is a selective beta blocker that specifically targets β2 receptors, which are primarily located in the smooth muscle of the airways and peripheral vasculature. Inhibition of β2 receptors leads to bronchoconstriction and vasoconstriction, making it unsuitable for managing conditions such as hypertension.
**Option C:** This is a selective beta blocker that specifically targets β1 receptors, but its mechanism of action is different from the correct answer. It is a β1 receptor antagonist that reduces heart rate and contractility, but its effects on cardiac output and peripheral vasculature are less pronounced.
**Clinical Pearl / High-Yield Fact**
When selecting a beta blocker for managing hypertension or angina, it is essential to consider the patient's cardiovascular risk factors, including heart failure, asthma, or COPD. Selective beta blockers, such as those that target β1 receptors, are generally preferred over non-selective beta blockers to minimize the risk of bronchoconstriction and peripheral vasoconstriction.
**Correct Answer: C. Metoprolol**