**Question:** The following are given intradermally EXCEPT:

A. Antibody
B. Antigen
C. Vaccinations
D. Local anesthetics

**Core Concept:** Intradermal injection is a method of administering substances directly into the dermal layer of the skin, usually for diagnostic or vaccination purposes.

**Why the Correct Answer is Right:** Antibodies (A) are large proteins produced by the immune system in response to foreign substances, not substances that are administered into the skin. Antigens (B) are substances that trigger the immune response, but they are typically administered along with antibodies or other immune components. Vaccinations (C) involve introducing a weakened or inactivated pathogen into the body to stimulate an immune response, not an intradermal injection. Local anesthetics (D) are substances used to temporarily numb a specific area of the skin, which is not the purpose of intradermal injections.

**Why Each Wrong Option is Incorrect:** Antibodies are too large to be administered via intradermal injection, leading to the exclusion of option A. Antigens are also administered along with antibodies or other immune components, making option B incorrect. Intradermal injections are typically used for vaccinations, making option C irrelevant to the intradermal injection method. Local anesthetics are administered for pain relief, not intradermal injections, making option D irrelevant to the method of administration.

**Clinical Pearl:** Intradermal injections are commonly used for vaccinations, skin tests, and diagnostic purposes. They are typically administered into the dermal layer using a specific technique involving a shallow puncture, aiming for the dermal layer, and counting 3-4 papules for an effective injection. Intradermal injections can be used to administer antigens, vaccines, or diagnostic substances.

**Correct Answer:** Local anesthetics (D) are NOT given intradermally, as they are administered for pain relief and are not relevant to the intradermal injection method.