Medical MCQ-The following are features of polycythemia rubra vera, except -

Increased red cell mass

Low aerial oxygen saturation

Presence of JAK2 mutation

Splenomegaly

Question Category:

Correct Answer:

Low aerial oxygen saturation

Description:

In PV, the major pathogenetic mechanism is a tyrosine kinase JAK2 mutation which removes the autoinhibitory control & activates the kinases.

Due to erythrocytosis, red cell mass will be increased .Splenomegaly produces abdominal fullness.But in PV, oxygen saturation will be high.

Reference :Harsh mohan textbook of pathology sixth edition pg no 359.

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