Microbiology The first step in fructose metabolism in the liver is A Isomerization of glucose B Phosphorylation to fructose 1, 6 bisphosphate by ATP C Phosphorylation to fructose 6 phosphate by ATP D Phosphorylation to fructose 1 phosphate by ATP 💡 Explanation The first step in fructose metabolism in the liver is ✓ Correct Answer: D. Phosphorylation to fructose 1 phosphate by ATP