**Core Concept**
The first epiphyseal centre to appear is related to the process of endochondral ossification, which is a type of bone formation where cartilage templates are replaced by bone tissue. This process is crucial for the growth and development of long bones in children and adolescents.

**Why the Correct Answer is Right**
The first epiphyseal centre appears in the proximal end of the humerus, typically around 3-4 months of gestation. This is due to the presence of a cartilaginous template that eventually gives rise to the bone tissue. The epiphyseal plates, located at the ends of long bones, are areas of high cellular activity where cartilage is constantly being replaced by bone tissue, allowing for the growth and elongation of bones.

**Why Each Wrong Option is Incorrect**
**Option A:** This is incorrect as the first epiphyseal centre does not appear in the distal end of the femur. While the distal femur does develop an epiphyseal centre, it appears later than the proximal end of the humerus.
**Option B:** This is incorrect as the first epiphyseal centre does not appear in the proximal end of the tibia. While the proximal tibia does develop an epiphyseal centre, it appears later than the proximal end of the humerus.
**Option C:** This is incorrect as the first epiphyseal centre does not appear in the distal end of the humerus. While the distal humerus does develop an epiphyseal centre, it appears later than the proximal end of the humerus.

**Clinical Pearl / High-Yield Fact**
It's essential for medical professionals to understand the timeline of epiphyseal centre appearance, as delays or abnormalities in this process can lead to growth disorders or other skeletal issues.

**Correct Answer: D. Proximal end of the humerus.**