The Finnish type of congenital nephritic syndrome occurs due to gene mutation affecting the following protein –
Correct Answer: Nephrin
Description: Congenital nephrotic syndrome
Infant who develop nephrotic syndrome within the first 3 months of life are considered to have congenital nephrotic syndrome.
The most common cause of this syndrome is finnish-type congenital nephrotic syndrome, an autosomal recessive disorder.
Two most common genes involved are -
i) NPHS1 --> Coding for nephrin and results in finnish-type nephrotic syndrome.
ii) NPHS2 --> Coding for Podocin and results in FSGS.
Other important genes involved in steroid - resistant nephrotic syndrome
Category:
Pediatrics
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