## **Core Concept**
Trisomy 18, also known as Edwards syndrome, is a genetic disorder caused by the presence of an extra copy of chromosome 18. This condition leads to severe developmental delays and life-threatening medical problems. The eponymous name is derived from the scientist who first described the condition.

## **Why the Correct Answer is Right**
The correct answer, Edwards, is attributed to John Hilton Edwards, a British geneticist who first described the condition in 1960. Edwards syndrome is characterized by growth deficiency, intellectual disability, and a distinct set of physical anomalies. The presence of an extra chromosome 18 disrupts normal development, leading to the severe manifestations of this syndrome.

## **Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not correspond to the known eponym for Trisomy 18.
* **Option B:** This option is incorrect as it does not accurately represent the scientist associated with the description of Trisomy 18.
* **Option C:** This option is incorrect because, although it might seem plausible, it does not correctly identify John Hilton Edwards.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that Trisomy 18 (Edwards syndrome) has a very poor prognosis, with most affected individuals not surviving beyond early childhood due to severe medical complications. Clinicians should be aware of the distinct physical features and severe developmental issues associated with this condition.

## **Correct Answer:** . Edwards.