Medicine The earliest phenotypic manifestation of idiopathic hereditary hemochromatosis is A Postprandial increase in serum iron concentration B Decreased serum ferritin level C Slate grey pigmentation of skin D Increased transferrin saturation 💡 Explanation The earliest phenotypic manifestation of idiopathic hereditary hemochromatosis is ✓ Correct Answer: D. Increased transferrin saturation