The drug which is not suitable for patients with acute porphyria for intravenous induction is –
Correct Answer: Thiopentone sodium
Description: All barbiturates (including thiopentone) are absolutely contraindicated.
There is controversy regarding etomidate because some text books (miller) consider it safe, while other (Lee, Wylie), consider it unsafe :-
Miller (7th/e 1115) has given etomidate amongst the safe drugs.
Lee and Wylie have opinion different to Miller :-
"Etomidate is potentially porphyriogenic in animal models and at least one crisis has followed its use in human subjects, although its safe use has also been reported, on balance, etomide should be considered unsafe".
─ Wylie
"Etomidate should probably be avoided because it is potentially porphyrinogenic in animals, although reports in humans are conflicting".
─ Lee
Anyways, whatever opinion about etomidate, the answer of this question is thiopentone for sure as there is no confusion about contraindication of barbiturates in porphyria.
Category:
Anaesthesia
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now