- Rifampicin, ceftriaxone and ciprofloxacin are used for the prophylaxis of meningococcal meningitis. - Ceftriaxone is most effective drug for prophylaxis of meningococcal meningitis, however it is injectable drug. - Resistance to rifampicin has been repoed in many meningococci, so it is not preferred these days. - The drug of choice for prophylaxis of meningococcal meningitis should be chosen as Ciprofloxacin > Rifampicin > Ceftriaxone