The classic triad of congenital rubella includes all except –
Correct Answer: Retinitis
Description: Congenital rubella syndrome
Maternal viremia associated with rubella infection during pregnancy may result in infection of the
placenta and fetus.
The most important factor in the pathogenicity of rubella virus for the fetus is the gestational age at the time
of infection.
“In general, the earlier in pregnancy infection occurs, the greater the damage to the fetus. Maximum damage to the fetus occurs when infection is acquired in the first trimester of pregnancy”.
Fetus infected in the twentieth week may have isolated deafness.
Clinical manifestations
The classical triad of congenital rubella consists of cataract, deafness and congenital heart diseases.
Laboratory diagnosis
Isolation of virus in cell cultures of throat samples, urine or other secretions.
Normally, maternal rubella antibodies in the form of IgG is transferred to infants and is gradually last over a period of 6 months. Persistent beyond 1 year in an un vaccinated child suggests the diagnosis of congenital rubella.
Presence of Ig M antibodies is diagnostic.
PCR for rubella RNA
Category:
Microbiology
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