The cause of oedema in Nephritic syndrome is-
**Core Concept**
Nephritic syndrome is characterized by inflammation of the glomeruli, leading to hematuria, proteinuria, and edema. The underlying pathophysiological mechanism involves the loss of negatively charged molecules, including albumin and other plasma proteins, due to damage to the glomerular basement membrane and podocytes.
**Why the Correct Answer is Right**
The correct answer is related to the reduction in the oncotic pressure caused by the loss of plasma proteins. Normally, the oncotic pressure exerted by albumin and other plasma proteins helps retain fluid within the blood vessels. However, in nephritic syndrome, the damaged glomeruli allow proteins to leak into the urine, reducing the oncotic pressure and causing fluid to shift into the interstitial space, resulting in edema.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the pathophysiology of edema in nephritic syndrome. In contrast, **Option C** is correct because it accurately describes the pathophysiological mechanism of edema in nephritic syndrome.
**Option B:** This option is incorrect because it is more relevant to nephrotic syndrome, where there is significant loss of albumin and other plasma proteins through the glomeruli, leading to hypoalbuminemia and edema.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that nephritic syndrome is characterized by inflammation of the glomeruli, whereas nephrotic syndrome is characterized by significant proteinuria. The distinction between these two conditions is crucial for appropriate diagnosis and treatment.
**Correct Answer: C. Reduced oncotic pressure due to loss of plasma proteins.**