Medical MCQ-The catabolite repression is mediated by a catabolite gene activator protein (CAP) in conjunction with:

The catabolite repression is mediated by a catabolite gene activator protein (CAP) in conjunction with:

AMP

GMP

c-AMP

C-GMP

Question Category:

Biochemistry

Correct Answer:

c-AMP

Description:

Ans. C. c-AMPAttachment of RNA polymerase to the promoter site requires the presence of a CAP bound to C-AMP. The presence of glucose lowers the intracellular concentration of c-AMP by inactivating the enzyme adenylate cyclase responsible for the synthesis of c-AMP. Therefore, the binding of RNA polymerase to DNA (due to the absence of CAP-c-AMP) and the transcription are negligible in the presence of glucose.

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